Baldridge Lab

Biological Chemistry

University of Michigan Medical School

  • Everyone has tried to fit pieces of something they've broken back together to make it work again.  This is one approach we use in our everyday science

    Everyone has tried to fit pieces of something they've broken back together to make it work again. This is one approach we use in our everyday science

  • Liposomes!

    Liposomes!

  • Beautiful.

    Beautiful.

  • Toothless... the workhorse of our lab...

    Toothless... the workhorse of our lab...

  • Our favorite protein quality control system.

    Our favorite protein quality control system.

  • Proteoliposomes float to the top!

    Proteoliposomes float to the top!

  • This is home for our yeasty-beasties

    This is home for our yeasty-beasties

  • Our model organism of choice.

    Our model organism of choice.

  • Proteoliposomes imaged with a single-molecule setup

    Proteoliposomes imaged with a single-molecule setup

  • mScarlet-I purification

    mScarlet-I purification

  • View from the lab

    View from the lab

Protein Quality Control at Cellular Membranes

Our lab focuses on the mechanisms that cells use to recognize and dispose of misfolded proteins within their organelles. These processes are remarkably conserved among eukaryotes and we use Saccharomyces cerevisiae as a model system because of its simplicity relative to "higher" eukaryotes.

Selected Publications

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Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Moochickal Assainar B, Ragunathan K, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

View on PubMed »

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumenĀ 

Sharninghausen R, Hwang J, Dennison D, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

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Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function.

Peterson BG, Hwang J, Russ JE, Schroeder J, Freddolino PL, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

View on PubMed »

The ERAD system is restricted by elevated ceramides.

Hwang J, Peterson BG, Knupp J, Baldridge RD

Science Advances, 2023, 9 (2), eadd8579

View on PubMed »

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1.

Peterson BG, Glaser ML, Rapoport TA, Baldridge RD

eLife, 2019, 8

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Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

View on PubMed »

Latest News

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2023.08.03

He did it!

Congratulations to Dr. Brian Peterson! The first PhD from the lab!

2023.05.18

Congratulations to Evan!

Evan earned his MSc in Biological Chemistry.

2023.01.01

Too many things stuck together (v3… Jenn and Jeremy were both selected for NIH training grants!)

Jenn Russ was selected for the GTP (a highly competitive Genetics Training Program T32 training grant)!

Jeremy Dortch was selected for the PSTP (a highly competitive Pharmacological Sciences Training Program T32 training grant)!

An important honor for amazing students.

Affiliations

Support

Damon Runyon Cancer Research Foundation
 University of Michigan Biological Sciences Scholars Program
University of Michigan Medical School
National Institutes of General Medical Sciences