Baldridge Lab

Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Moochickal Assainar B, Ragunathan K, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen 

Sharninghausen R, Hwang J, Dennison D, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function.

Peterson BG, Hwang J, Russ JE, Schroeder J, Freddolino PL, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

The ERAD system is restricted by elevated ceramides.

Hwang J, Peterson BG, Knupp J, Baldridge RD

Science Advances, 2023, 9 (2), eadd8579

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1.

Peterson BG, Glaser ML, Rapoport TA, Baldridge RD

eLife, 2019, 8

Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distribution.

Hankins HM, Baldridge RD, Xu P, Graham TR

Traffic (Copenhagen, Denmark), 2015, 16 (1), 35-47

Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport.

Xu P, Baldridge RD, Chi RJ, Burd CG, Graham TR

The Journal of Cell Biology, 2013, 202 (6), 875-86

Type IV P-type ATPases distinguish mono- versus diacyl phosphatidylserine using a cytofacial exit gate in the membrane domain.

Baldridge RD, Xu P, Graham TR

The Journal of Biological Chemistry, 2013, 288 (27), 19516-27

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

Baldridge RD, Graham TR

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (5), E358-67