Baldridge Lab

Biological Chemistry

University of Michigan Medical School

  • Everyone has tried to fit pieces of something they've broken back together to make it work again.  This is one approach we use in our everyday science

    Everyone has tried to fit pieces of something they've broken back together to make it work again. This is one approach we use in our everyday science

  • Liposomes!

    Liposomes!

  • Beautiful.

    Beautiful.

  • Toothless... the workhorse of our lab...

    Toothless... the workhorse of our lab...

  • Our favorite protein quality control system.

    Our favorite protein quality control system.

  • Proteoliposomes float to the top!

    Proteoliposomes float to the top!

  • This is home for our yeasty-beasties

    This is home for our yeasty-beasties

  • Our model organism of choice.

    Our model organism of choice.

  • Proteoliposomes imaged with a single-molecule setup

    Proteoliposomes imaged with a single-molecule setup

  • mScarlet-I purification

    mScarlet-I purification

  • View from the lab

    View from the lab

Protein Quality Control at Cellular Membranes

Our lab focuses on the mechanisms that cells use to recognize and dispose of misfolded proteins from within their organelles. These processes are performed by integral membrane proteins and are remarkably well conserved among eukaryotes. We use Saccharomyces cerevisiae as a model system because of its simplicity relative to "higher" eukaryotes. In certain projects, our questions require us to use mammalian tissue culture systems.

Selected Publications

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Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD.

Moochickal Assainar B, Ragunathan K, Baldridge RD

Nature Communications, 2024, 15 (1), 1340

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Deep mutational scanning highlights a role for cytosolic regions in Hrd1 function.

Peterson BG, Hwang J, Russ JE, Schroeder JW, Freddolino PL, Baldridge RD

Cell Reports, 2023, 42 (11), 113451

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Identification of ERAD-dependent degrons for the endoplasmic reticulum lumenĀ 

Sharninghausen R, Hwang J, Dennison D, Baldridge RD

BioRxiv : the Preprint Server for Biology, 2023

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The ERAD system is restricted by elevated ceramides.

Hwang J, Peterson BG, Knupp J, Baldridge RD

Science Advances, 2023, 9 (2), eadd8579

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Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1.

Peterson BG, Glaser ML, Rapoport TA, Baldridge RD

eLife, 2019, 8

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Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD.

Baldridge RD, Rapoport TA

Cell, 2016, 166 (2), 394-407

View on PubMed »

Latest News

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2023.12.20

Thanks to the W. M. Keck Foundation!

The Baldridge Lab and Tsai lab received a grant from the W. M. Keck Foundation to develop novel targeted protein degradation strategies for targeting proteins from the ER to inhibit viral biogenesis and infection.

2023.12.15

She did it!

Congratulation to Dr. Devon Dennison! She earned the second PhD from the lab with her thesis titled: “Exploring the Mechanics of Golgi-localized Tul1 Selective Degradation.”

2023.08.03

He did it!

Congratulations to Dr. Brian Peterson! The first PhD from the lab!

Affiliations

Support

W. M. Keck Foundation
Damon Runyon Cancer Research Foundation
 University of Michigan Biological Sciences Scholars Program
University of Michigan Medical School
National Institutes of General Medical Sciences