Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.
Hwang J, Qi L
Trends in Biochemical Sciences, 2018, 43 (8), 593-605
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Jiwon Hwang, PhD
Research Investigator
Location: 3200 MSRB3
Lab Phone: (734) 936-3440
Email: jiwonh@med.umich.edu
Jiwon received her B.S. and M.S in Biochemistry from Yonsei University, Seoul in South Korea. Her Master’s work focused on the regulation of Cullin E3 ubiquitin ligases in mammalian cells. During her PhD studies with Dr. Rob Kalejta at University of Wisconsin-Madison, her research focused on the mechanisms that mediate viral gene activation during human cytomegalovirus infection related to ubiquitin/SUMO pathways (2005-2011). For her postdoctoral training, she continued to build on her previous training in ubiquitin by moving into a membrane-anchored E3 ubiquitin ligase complex. In the lab of Dr. Ron Kopito at Stanford University, she analyzed the Hrd1 ERAD E3 ligase complex using genome-edited Hrd1-TAP knock-in mammalian cell (2011-2014). For family reasons, she moved to Baltimore and continued her postdoctoral training in Peter Espenshade’s lab at Johns Hopkins University. She investigated the molecular mechanism of yeast SREBP activation, which led to the identification of Golgi membrane-associated rhomboid Intramembrane protease in addition to the Dsc E3 ubiquitin ligase in the pathway (2014-2017). Her current projects In the Baldridge lab are to identify endogenous Hrd1 substrates and to investigate the influence of the membrane on ERAD function.
Awards and Honors
- Protein Folding Diseases Initiative - Best Research Faculty Poster - University of Michigan (2019)
- International Herpesvirus Workshop (IHW) Travel Award, IHW (2010)
- Vilas Travel Grant, University of Wisconsin-Madison (2010)
- Peer mentor Award, University of Wisconsin-Madison (2010)
- Vilas Travel Grant, University of Wisconsin-Madison (2009)
- Research Fellowship, Protein Network Research Center (PNRC), Korea (2003-2004)
- Best Poster Award, 59th the Biochemical Society of the Republic of Korea (2002)
- BK21 Scholarship for graduate training, Korea (2001-2003)
- Honors Scholarship, Yonsei University, Korea (1998-2000)
Publications
Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.
Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR
The Journal of Biological Chemistry, 2017, 292 (22), 9104-9116
View More »Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2.
Hwang J, Espenshade PJ
The Biochemical Journal, 2016, 473 (16), 2463-9
View More »A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.
Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ
The EMBO Journal, 2016, 35 (21), 2332-2349
View More »Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle.
Winkler LL, Hwang J, Kalejta RF
Journal of Virology, 2013, 87 (8), 4665-71
View More »Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication.
Hwang J, Saffert RT, Kalejta RF
MBio, 2011, 2 (2), e00023-11
View More »Ubiquitin-independent proteasomal degradation during oncogenic viral infections.
Hwang J, Winkler L, Kalejta RF
Biochimica Et Biophysica Acta, 2011, 1816 (2), 147-57
View More »In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation.
Hwang J, Kalejta RF
Methods (San Diego, Calif.), 2011, 55 (2), 160-5
View More »Human cytomegalovirus protein pp71 induces Daxx SUMOylation.
Hwang J, Kalejta RF
Journal of Virology, 2009, 83 (13), 6591-8
View More »Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells.
Hwang J, Kalejta RF
Virology, 2007, 367 (2), 334-8
View More »TIP120A associates with cullins and modulates ubiquitin ligase activity.
Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB
The Journal of Biological Chemistry, 2003, 278 (18), 15905-10
View More »TIP120A associates with unneddylated cullin 1 and regulates its neddylation.
Hwang JW, Min KW, Tamura TA, Yoon JB
FEBS Letters, 2003, 541 (1-3), 102-8
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